Isradipine: Shutting the Door on Calcium Channels to Slow the Progression of Parkinson’s?

Journey with Parkinson's

Vineyard“The very least you can do in your life is figure out what you hope for. And the most you can do is live inside that hope. Not admire it from a distance but live right in it, under its roof.” Barbara Kingsolver

Doors Opening and Closing, an Analogy for Calcium Channels:  Carrie Newcomer sings “When one door closes another door opens wide/It’s hard to believe all of the locked doors I’ve tried.”  Each cell in our body requires nutrition and substances that deliver signals.  One such substance is calcium, a 2+ charged metal ion (like the Ion TV network slogan it is “positively” entertaining). Calcium uses cell-membrane-anchored channels to be transported from outside to inside the cell. Ion channels exist to selectively allow calcium the pathway into a cell.  Once inside the cell, calcium helps to promote muscle contraction, neurotransmission (signaling molecules released by a neuron and…

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